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Columbia Journal of Pharmaceutical Sciences
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ISSN Online: 2349-9907 | ISSN Print: 2350-014X
# Welcome To Columbia Journal of Pharmaceutical Sciences (CJPS)
Columbia Journal of Pharmaceutical Sciences (CJPS) is an official journal of the Columbia Institute of Pharmacy, Raipur, India. CJPS is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The CJPS seeks to set up an academic communicating platform for scientists all over the world. As well as contribute an international forum for all the researchers related to Pharmaceutical Sciences to share opinions and learn about important international breakthrough developments in drug discovery.
# Current Issue

Research article
New spectroscopy methods development for simultaneous estimation of Benazepril and Hydrochlorothiazide in pharmaceutical dosage form
S.J. Daharwal, Veena D. Singh
Abstract
A new, simple, rapid and novel spectrophotometric method has been developed for estimation of Benazepril (BENZ) and Hydrochlorothiazide (HCTZ) in bulk and combined pharmaceutical formulations using absorbance correction method (ACM). λmax of BENZ.............
Keywords: Benazepril (BENZ), Hydrochlorothiazide (HCTZ), Absorbance correction method (ACM), UV spectrophotometer.
Abstract | HTML Full Text | PDF |

Research article
Phytochemical Screening and Antimicrobial Activity of Ougeinia Oojeinensis Leaves
Jagdish Singh, Rajesh Gupta
Abstract
The present investigation was undertaken to evaluate the phytochemical and antimicrobial activity of the methanol and aqueous extracts of leaves of Ougeinia oojeinensis. The leaves extracts of Ougeinia oojeinensis were prepared using different sol.............
Keywords: Ougeinia oojeinensis, Phytochemical screening, Antimicrobial activity
Abstract | HTML Full Text | PDF |

Research article
Comparative Evaluation of Phytochemical Constituents of Some Plants of Solanaceae Family
Kalpana Gavande, Kirti Jain, Bharti Jain, Rakesh Mehta
Abstract
The identification of primary and secondary constituents has become the most important tool to know the active principles of various medicinal plants. The present study was aimed at identification and evaluation of certain phytochemicals in Withan.............
Keywords: Withania somnifera, Solanum nigrum, Solanum indium, Solanum xanthocarpum, Quantitative analysis
Abstract | HTML Full Text | PDF |

Review Article
Future Prospects and Aspects of Herbal Drug Discovery in Herbal Medicines
Meenakshi Ratra, Rajesh Gupta
Abstract
Herbal drugs constitute a major share of all the officially recognised systems of health in India viz. Ayurveda, Yoga, Unani, Siddha, Homeopathy and Naturopathy, except Allopathy. More than 70% of India’s 1.1 billion population still use these n.............
Keywords: Herbal Medicines, herbal drug discovery, Ethnopharmacology
Abstract | HTML Full Text | PDF |

Review Article
Optimization and Scale Up of Polymeric Matrix Based Extended Release Tablets Formulations – A Review
Devendra K. Dewangan, Rajani Chouhan, Jaya Dwivedi, Arvind Kumar Jha
Abstract
Process optimization and scale up is one of the essential elements of technology transfer of Pharmaceutical products from R & D to Pilot plant or commercial level. The major purpose of carrying out PO studies is to identify and control Critical Pr.............
Keywords: Optimization, Scale up, Extended Release Tablets, Matrix, Design of experiments
Abstract | HTML Full Text | PDF |

Review Article
A Review on Anticancer Properties of Herbal Medicines
Ashish Kumar Netam, Jhakeshwar Prasad, Bholenath Tamrakar, Tapan Kishor Nayak, Kunal Chandrakar, Sandip Prasad Tiwari
Abstract
There are tremendous reserves of organic compounds found in many plants on Earth that only a very small amount of which as an anti-cancer compounds tested and used. Worldwide endeavours are underway to discover new anti-cancer drugs. Nowadays, there .............
Keywords: Carcinogenic, Anti cancer, Herbal drug, Medicinal plants, Apoptosis
Abstract | HTML Full Text | PDF |

Review Article
A Review on Effect of Medicinal Plants and Treatment of Antidepressant
Ashish Kumar Netam, Trilochan Satapathy, Jhakeshwar Prasad, Prashant Tiwari, Uday Chand
Abstract
Depression is a heterogeneous group of brain disorders characterized by a wide range of symptoms that result in psychomotor and cognitive impairments. Depression is accompanied with loss of pleasure or interest, feeling of guilt, decreased energy and.............
Keywords: Depression; Neuropsychiatric disorder; CNS related disorder; Antidepressant; Medicinal plant
Abstract | HTML Full Text | PDF |

Review Article
Aesculus hippocastanum: Risks Vs Therapeutic Opportunities: A Mechanism Based Review
Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy, Bibhas Pandit, Bholenath Tamrakar, Prasanna Kumar Panda, Gitanjali Mishra
Abstract
Natural products possess wide range of diversity of multi-dimensional chemical structure and diversified biological function modifiers as well as significant role in health system all over the world for both humans and animals. An Aesculus hippocasta.............
Keywords: Aesculus hippocastanum, Aecin, anti-oxidants, bioflavonoid
Abstract | HTML Full Text | PDF |

Review Article
Antioxidants and their Implication
Jhakeshwar Prasad, Ashish Kumar Netam, Trilochan Satapathy, Akanksha Gujar, Vikash Sharma
Abstract
Hyperglycemia promote auto-oxidation of glucose to type free radicals. The production of free radicals outside the scavenging abilities of endogenous antioxidant resistance results in microvascular dysfunction. Antioxidants such as N-acetylcysteine, .............
Keywords: Antioxidants; diabetes mellitus; free radicals; Dietary food
Abstract | HTML Full Text | PDF |

Review Article
Bioartificial Kidney: A Nanotechnology Based Device For High Efficiency Toxin Clearance
Jhakeshwar Prasad, Ashish Kumar Netam, Trilochan Satapathy, Shikha Vijay Rane, Prashant Tiwari, Sandeep Prasad Tiwari, Amit Roy
Abstract
Kidneys play a crucial role in removal of the waste products and excess water from the body there by maintaining fluid balance. In case of a human, person’s kidneys process about 200 quarts of blood to sift out roughly 2 quarts of waste products in.............
Keywords: Artificial kidneys; Kidney failure; filtering efficiency; dialysis; transplantation
Abstract | HTML Full Text | PDF |

Review Article
Complication and Management of Diabetes Mellitus: An Overview
Ashish Kumar Netam, Jhakeshwar Prasad, Prashant Tiwari, Kunal Chandrakar, Sandhya Mishra, Lalita Sandey, Disha Kesharwani
Abstract
Diabetes is a disease chronic disease which affects global population from long time. Diabetes mellitus is a group of physiological dysfunctions characterized by hyperglycemia resulting directly from insulin resistance, inadequate insulin secretion, .............
Keywords: Diabetes, Diabetic retinopathy, Diabetic Complications
Abstract | HTML Full Text | PDF |

Review Article
Computational Biomodeling: A useful tool in new Drug Discovery
Jhakeshwar Prasad, Ashish Kumar Netam1, Trilochan Satapathy, Bibhas Pandit, Arvind Verma1, Prasanna Kumar Panda, Gitanjali Mishra
Abstract
In the changing trend of education need of computer its knowledge is now necessary. Additionally computer helps in demonstration of drug effects on whole animal or on isolated tissues of practical pharmacology, so it is a rapidly ubiquitously growing.............
Keywords: Computational Biomodeling, simulation, Drug Discovery, Structural modeling
Abstract | HTML Full Text | PDF |

Review Article
Ethnopharmacological and Pharmacognostical Investigation On Plumbago zeylanica Linn: An Important Indigenous Plant of Chhattisgarh used in Diabetes
Shiv Kumar Bhardwaj, Shiv Shankar Shukla, Ravindra Pandey, Ashish Kumar Netam, Jhakeshwar Prasad, Tapan Kishor Nayak
Abstract
Herbal medicines are always in great demand they are in use since the time of immortal. People all around the globe are dependent on herbal medicines because of their non-violent and non-toxic nature. All though there are so many alternative methods .............
Keywords: Plumbago zeylanica, Plumbagin, Ayurveda, Microscopic, Pharmacological
Abstract | HTML Full Text | PDF |

Review Article
A Review on Ethnopharmacological Approaches to Wound Healing and Curative Progression
Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy, Parag Jain, Aditya Singh Thakur, Prasanna Kumar Panda, Gitanjali Mishra
Abstract
Wound is an injury to living tissue caused by a cut, blow or broken mainly the outer membrane. Wound healing requires a precised control for derivative and regenerative processes, which is involved in several types of cell and complex interactions be.............
Keywords: Wound healing; Antioxidant; Skin Protection; Inflammation; Herbal Medicines
Abstract | HTML Full Text | PDF |

Review Article
Functional Role of Various Neurotransmitters in the Management of Epilepsy
Ashish Kumar Netam, Jhakeshwar Prasad, Ruchi Bhattacharya, Renuka Verma, Mahendra Kumar Sahu , Ashish Tamrakar, S. Prakash Rao
Abstract
Epilepsy is a group of neurological disorders characterized by recurrent seizure followed by spontaneous resolution, loss of conscious with or without characteristic body moment. These episodes can result in physical injuries including occasionally b.............
Keywords: Epilepsy, Seizure, Tonic, Clonic, Atonic, Myoclonic, Anticonvulsant
Abstract | HTML Full Text | PDF |

Review Article
Molecular Targeted Therapy of Cancer: The Progress and Future Prospect
Jhakeshwar Prasad, Ashish Kumar Netam, Trilochan Satapathy, Sangam Chandrakar, Shailendra Sharma
Abstract
Cancer has become a major public health problem worldwide. Researches focus on the new approaches for cancer treatments that involve the specific targets of the cancer disease. The premise of targeted therapy in oncology is the fundamental reliance o.............
Keywords: Cancer; Molecular Targeted Therapy; Drug resistance.
Abstract | HTML Full Text | PDF |

Review Article
Pathophysiology and Current Therapies For Hypertension: A Review
Ghanshyam Patel, Trilochan Satapathy, Jhakeshwar Prasad, Ashish Kumar Netam, Punita Khunte, Suman Raj, Raj Kumar Tiwari, Shipra Pandey
Abstract
Hypertension is a chronic disorder characterized by a persistently elevated blood pressure exceeding 140/90 mmHg or greater. Many antihypertensive agents are used for treatment of hypertension like Thiazide, loop, and potassium-sparing diuretics, cal.............
Keywords: Hypertension, Antihypertensive agent, Medicinal plants and their Pharmacological activity.
Abstract | HTML Full Text | PDF |

Review Article
Physicochemical Investigation and Anthelmintic Activity of Eucalyptus globulus Leaves Extracts
Nayak S, Barik S., Trilochan Satapathy, Jhakeshwar Prasad, Ashish Kumar Netam, Usha Dewangan, Sandeep Prasad Tiwari, Pragyashila Bhatpahri
Abstract
To know the anthelmintic activity of leave Eucalyptus globulus, the present investigation was performed. For that purpose, at first, physicochemical parameters like ash value and extractive value of the powder sample (Eucalyptus globulus) were estima.............
Keywords: Eucalyptus globulus, Acetone extract, Chloroform extract, Anthelmintic activity
Abstract | HTML Full Text | PDF |

Review Article
Recent Approach on Role of Endothelin in Cardiovascular Disorder: A Mechanism Based Review
Prasanna Kumar Panda, Akanksha Gujar, Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy, Shikha Vijay Rane, Gitanjali Mishra
Abstract
Endothelin (ET) is a potent vasoconstrictive peptide that was isolated initially from the conditioned medium of cultured endothelial cells. In 1988, details of the isolation and identification, amino acid sequence, cDNA sequence and pharmacology of E.............
Keywords: Endothelin, signaling pathway, cardiovascular diseases, vasoconstrictive peptide
Abstract | HTML Full Text | PDF |

Review Article
Recent Impactful Applications of Biosenssor: A Critical Review
Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy, Bibhas Pandit ,Sangam Chandrakar, Prasanna Kumar Panda, Gitanjali Mishra
Abstract
Biosensors are the devices that capture the biological signal and convert it into a detectable electrical signal. It involves the combination of biological entities like DNA, RNA, and proteins/enzymes to the electrochemical transducers in order to de.............
Keywords: Transducer; Bioanalyte; Biosensors; Phage-sensor; Surface Plasmon Resonance (SPR) sensor; Amperometric sensor; Conductimetric sensor
Abstract | HTML Full Text | PDF |

Editorial
The Role of Atrial Natriueretic Peptide: A Review
Ashish Kumar Netam, Trilochan Satapathy, Jhakeshwar Prasad, Kunal Chandrakar, Rajni Yadav, Anjali Sahu, Sandeep Prasad Tiwari, Amit Roy
Abstract
The Atrial Natriuretic Peptide (ANP) is a cardiac hormone secreted by the atrial myocytes present in the heart; it is involved in the homeostatic maintenance of blood volume and atrial blood pressure. It is also known by other name like atrial natriu.............
Keywords: Atrial Natriuretic Peptide, Natriuresis, hypertension, homeostatic maintenance.
Abstract | HTML Full Text | PDF |

Review Article
A Review on The Role of Natural Antioxidants: Its Sources, Mechanisms of Action, and Potential Medicinal and Pharmacological Applications
Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy, Bibhas Pandit, Aditya Singh Thakur, Deepak Kumar Lanjhi, Amit Roy
Abstract
While use of synthetic antioxidants (such as butylated hydroxytoluene and butylated hydroxyanisole) to maintain the quality of ready-to-eat food products has become commonplace, consumer concern regarding their safety has motivated the food industry .............
Keywords: Antioxidants, diabetes mellitus, free radicals, Dietary food
Abstract | HTML Full Text | PDF |

Review Article
Role of Some Natural Bioactive Compounds in the Treatment of Diabetes
Jhakeshwar Prasad, Ashish Kumar Netam, Rishabh Sharma, Chandra Prakash Dwivedi, Bibhas Pandit, Raj Kumar Tiwari, Trilochan Satapathy, Amit Roy
Abstract
Over the last century human life and food habits have drastically changed which lead to various chronic diseases. Diabetes is one such disease which is causing serious problems to human health. Diabetes mellitus is a metabolic disorder characterized .............
Keywords: Diabetes, Diabetes mellitus, Complication of the insulin therapy, Pharmacological treatment.
Abstract | HTML Full Text | PDF |

Review Article
Structural and Functional Role of Ion Channels: A Mechanism Based A Review
Ashish Kumar Netam, Jhakeshwar Prasad, Raj Kumar Tiwari, Bibhas Pandit, Vikash Sharma, Pushpa Prasad, Rajni Yadav
Abstract
The field of ion channels has entered into a rapid phase of development in the last few years,. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplif.............
Keywords: Ion channels K+ channel acetylcholine receptor membrane, subunits, Response.
Abstract | HTML Full Text | PDF |

Review Article
Therapeutic Approaches for the Management of Parkinsons Disease
Ashish Kumar Netam, Jhakeshwar Prasad, Uday Chand, Trilochan Satapathy, S. Prakash Rao, Banadip Roy, Ravindra Pandey, Shiv Shankar Shukla, Sandeep Prasad Tiwari
Abstract
Parkinsons disease(PD) is a chronic, neuro generative and movement disorder, which involves progressive fall of motor function due to loss of dopamine producing cells particularly in the substantial nigra area of the brain. It is the most common neur.............
Keywords: Parkinsons disease, Neurogenerative disorder, Antioxidant remedies, Herbal medicines.
Abstract | HTML Full Text | PDF |
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